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A2093 Sigma-Aldrich

Aspirin

meets USP testing specifications

Synonym: 2-Acetoxybenzoic acid, O-Acetylsalicylic acid, ASA, Acetylsalicylic acid, Aspirin

  • CAS Number 50-78-2

  • Linear Formula 2-(CH3CO2)C6H4CO2H

  • Molecular Weight 180.16

  •  Beilstein/REAXYS Number 779271

  •  EC Number 200-064-1

  •  MDL number MFCD00002430

  •  PubChem Substance ID 24890623

  •  NACRES NA.21

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Properties

Related Categories Analytical/Chromatography, Core Bioreagents, Enzyme Inhibitors, Pharmacopoeia, Pharmacopoeia A-Z,
Agency/Method   meets USP testing specifications
Quality Level   200
mp   134-136 °C (lit.)
Featured Industry   Pharmaceutical (small molecule)
SMILES string   CC(=O)Oc1ccccc1C(O)=O
InChI   1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
InChI key   BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Gene Information   human ... ITGA2B(3674), PTGS1(5742), PTGS2(5743)

Description

General description

Aspirin (acetylsalicylic acid) is a nonsteroidal anti-inflammatory drug. It occurs as white crystalline powder and is derived from salicylic acid.

Application

Aspirin has been used:
• as a stabilizer for blood during 13,14-dihydro-15-keto-prostaglandin F2α (PGFM) measurement
• to evaluate cell viability of BV-2 microglial cell line
• in morphogenesis assay

Packaging

100, 500 g in poly bottle

Biochem/physiol Actions

Aspirin is an analgesic and antipyretic agent used in the treatment of fever and pain as in arthritis. It is also associated with cardiovascular diseases.

Blocks the production of prostaglandins by inhibiting cyclooxygenase (prostaglandin H synthase), with greater selectivity toward the COX-1 isoform. The antithrombotic effect is due to the inhibition of COX-1 in platelets that blocks thromboxane production and platelet aggregation. Chemopreventive against colorectal and other solid tumors.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 1
RTECS 
VO0700000
Flash Point(F) 
482.0 °F
Flash Point(C) 
250 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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