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A3835 Sigma-Aldrich

Ascomycin from Streptomyces hygroscopicus var. ascomyceticus

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Description

General description

Chemical structure: macrolactam

Packaging

1 mg in glass bottle

Biochem/physiol Actions

Strong immunosuppressant; inhibits allogenic T-lymphocyte proliferation. It binds with high affinity to FKBP and inhibits calcineurin phosphatase in the nM range.

Linkage

An FK506 analog with an ethyl rather than an allyl group at position 21.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
KD4185000

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Immunology Research

The immune system is a complex network to detect and defend against non-self pathogenic agents, such as disease-causing viruses, bacteria, and other microorganisms. Various signaling pathways contrib...
Keywords: Antibiotics, Antifungals, Antivirals, Apoptosis, Bioactive small molecules, Cell signaling, Diabetes, Diseases, Immunology, Inflammation

LC/MS/MS Analysis of Immunosuppressant Drugs in Human Plasma on Ascentis® Express F5 after SPE Using HybridSPE®-Phospholipid

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Immunosuppressant Drugs in Human Plasma on Ascentis® Express F5 after SPE Using HybridSPE®-Phospholipid
Keywords: Chromatography, High performance liquid chromatography, Mass spectrometry, Sample preparations, Separation, Solid phase extractions, Solvents, Vitamins

LC/MS/MS Analysis of Immunosuppressant Drugs on apHera™ C18

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Immunosuppressant Drugs on apHera™ C18
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Solvents

Peer-Reviewed Papers
15

References

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