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A4599 SAFC

L-Arginine monohydrochloride

PharmaGrade, Ajinomoto, EP, JP, USP, Manufactured under appropriate GMP controls for pharma or biopharmaceutical production, suitable for cell culture

Synonym: (S)-(+)-2-Amino-5-[(aminoiminomethyl)amino]pentanoic acid monohydrochloride, (S)-(+)-Arginine hydrochloride

  • CAS Number 1119-34-2

  • Empirical Formula (Hill Notation) C6H14N4O2 · HCl

  • Molecular Weight 210.66

  •  Beilstein/REAXYS Number 3631658

  •  EC Number 214-275-1

  •  MDL number MFCD00064550

  •  PubChem Substance ID 57653852

  •  NACRES NA.26



Related Categories Amino Acids, Analytical/Chromatography, Biochemicals and Reagents, Pharmacopoeia, Pharmacopoeia A-Z,
biological source   non-animal source
Agency/Method   EP
product line   PharmaGrade
assay   ≥98.5%
form   crystalline powder
mfr. no.   Ajinomoto
application(s)   cell culture | mammalian: suitable
impurities   endotoxin, heavy metals, residual solvents, tested
solubility   H2O: 100 mg/mL
density   1.42 g/cm3 at 20 °C
anion traces   chloride (Cl-): 16.58-17.00%
  sulfate (SO42-): ≤0.020%
cation traces   As: ≤1.0 ppm
  NH4+: ≤0.02%
  heavy metals: ≤10 ppm
Featured Industry   Pharmaceutical (small molecule)
foreign activity   cytotoxicity, tested
SMILES string   Cl[H].N[C@@H](CCCNC(N)=N)C(O)=O
InChI   1S/C6H14N4O2.ClH/c7-4(5(11)12)2-1-3-10-6(8)9;/h4H,1-3,7H2,(H,11,12)(H4,8,9,10);1H/t4-;/m0./s1


General description

PharmaGrade products are manufactured under appropriate controls for use as a raw material in pharma or biopharmaceutical production. For more information on the PharmaGrade Program, visit sigma-aldrich.com/safc-pharmagrade.
To request the Enhanced Quality Product Documentation for this product, please contact Customer Support and select ‘Product Documentation’. Please note that access to the Enhanced Quality Product Documentation for this product requires a confidentiality disclosure agreement.


L-Arginine is a non-essential amino acid. It is used as a cell culture media component for the commercial biomanufacture of therapeutic recombinant proteins and monoclonal antibodies. L-Arginine monohydrochloride is a modified version of L-Arginine with improved solubility.

Biochem/physiol Actions

Substrate of nitric oxide synthase, which is converted to citrulline and nitric oxide (NO). Induces insulin release by a nitric oxide-dependent mechanism.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles

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