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A5139 Sigma-Aldrich

Asp-Phe methyl ester

≥98%

Synonym: N-(L-α-Aspartyl)-L-phenylalanine methyl ester, Asp-Phe-OMe, Aspartame

  • CAS Number 22839-47-0

  • Linear Formula HOOCCH2CH(NH2)CONHCH(CH2C6H5)COOCH3

  • Molecular Weight 294.30

  •  Beilstein/REAXYS Number 2223850

  •  EC Number 245-261-3

  •  MDL number MFCD00002724

  •  PubChem Substance ID 24890947

  •  NACRES NA.26

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Properties

Related Categories Biochemicals and Reagents, Dipeptides, Dipeptides and Tripeptides, Peptides
Quality Level   200
assay   ≥98%
form   powder
sweetness   160-200 × sucrose
color   white to off-white
storage temp.   2-8°C
SMILES string   COC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](N)CC(O)=O
InChI   1S/C14H18N2O5/c1-21-14(20)11(7-9-5-3-2-4-6-9)16-13(19)10(15)8-12(17)18/h2-6,10-11H,7-8,15H2,1H3,(H,16,19)(H,17,18)/t10-,11-/m0/s1
InChI key   IAOZJIPTCAWIRG-QWRGUYRKSA-N

Description

General description

Asp-Phe methyl ester (aspartame, APM, ASP), a dipeptide ester, is made up of phenyl alanine and aspartic acid. Its genotoxic effects have been investigated. Its interaction with certain hydrocolloids has been studied.

Application

Asp-Phe methyl ester is used for the preparation of Ad libitum Standard Chow, with ad libitum drinking water (animals control diet) containing Asp-Phe methyl ester. It is also used for the TFA diet preparation (TFA diet with ad lib drinking water contains Asp-Phe methyl ester.

Packaging

1, 5, 25 g in poly bottle

Biochem/physiol Actions

Asp-Phe methyl ester (Asp-Phe-OMe) is used as a synthetic sweeter, sugar substitute. Asp-Phe methyl ester is being studied for a variety of potential benefits as a nutrition supplement, such as the delay of osteoarthritis and modulation of rheumatoid factor activity. Asp-Phe methyl ester is being studied for its effect on thrombin activity and blood clotting.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 2
RTECS 
WM3407000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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