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A5585 Sigma-Aldrich

5-(N-Methyl-N-isobutyl)­amiloride

≥98% (TLC), powder

Synonym: MIA

  • CAS Number 96861-65-3

  • Empirical Formula (Hill Notation) C11H18ClN7O

  • Molecular Weight 299.76

  •  MDL number MFCD00078567

  •  PubChem Substance ID 24278228

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Properties

Related Categories A to C, Adenosinetriphosphatase (Na/K), Amiloride and Derivatives, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
Quality Level   200
assay   ≥98% (TLC)
form   powder
mp   200-201 °C
solubility   methanol: 9.80-10.20 mg/mL, clear, pale yellow to yellow
storage temp.   2-8°C
SMILES string   CC(C)CN(C)c1nc(N)c(nc1Cl)C(=O)NC(N)=N
InChI   1S/C11H18ClN7O/c1-5(2)4-19(3)9-7(12)16-6(8(13)17-9)10(20)18-11(14)15/h5H,4H2,1-3H3,(H2,13,17)(H4,14,15,18,20)
InChI key   RVIUMPLAOXSSGN-UHFFFAOYSA-N
Gene Information   human ... SCNN1A(6337), SCNN1B(6338), SCNN1D(6339), SCNN1G(6340)
mouse ... Scnn1a(20276), Scnn1b(20277), Scnn1d(140501), Scnn1g(20278)
rat ... Scnn1a(25122), Scnn1b(24767), Scnn1g(24768)

Description

Application

5-(N-Methyl-N-isobutyl)­amiloride is a potent blocker of the Na2/H+ antiport. 5-(N-Methyl-N-isobutyl)­amiloride has been used to study early cellular response to acidosis.

Packaging

25 mg in poly bottle

Biochem/physiol Actions

Potent blocker of the Na+/H+ antiport. Possible antitumor agent.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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