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A6804 Sigma-Aldrich

Amphotericin B from Streptomyces sp.

~80% (HPLC), suitable for plant cell culture, solubility: in DMF: 1 M HCl (3:1)clear to hazyslightly hazy

Synonym: Fungizone

  • CAS Number 1397-89-3

  • Empirical Formula (Hill Notation) C47H73NO17

  • Molecular Weight 924.08

  •  Beilstein/REAXYS Number 78342

  •  EC Number 215-742-2

  •  MDL number MFCD00877763

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Properties

InChI Key   APKFDSVGJQXUKY-INPOYWNPSA-N
assay   ~80% (HPLC)
application(s)   cell culture | plant: suitable
solubility   DMF: 1 M HCl (3:1): soluble, clear to slightly hazy
antibiotic activity spectrum   fungi
storage temp.   2-8°C

Description

Application

Recommended for antifungal use in cell culture media at 2.5 mg/L. Stable at 37 °C for 3 days.

Biochem/physiol Actions

Amphotericin B Streptomyces sp. Is a polyene antifungal antibiotic that forms membrane channels.

Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out. The product is most effective against fungi and yeast.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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A2411 Amphotericin B from Streptomyces sp., BioReagent, suitable for cell culture, ~80% (HPLC)

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