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A6825 Sigma-Aldrich

Amyloid β-Protein Fragment 10-20

≥97% (HPLC), lyophilized powder

  • CAS Number 152286-31-2

  • Empirical Formula (Hill Notation) C71H99N17O16

  • Molecular Weight 1446.65

  •  MDL number MFCD00467025

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Properties

assay   ≥97% (HPLC)
form   lyophilized powder
composition   Protein content, ≥70%
solubility   0.1% TFA: 1 mg/mL
storage temp.   −20°C
SMILES string   CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc2c[nH]cn2)NC(=O)[C@@H](NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](N)Cc3ccc(O)cc3)C(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](Cc5ccccc5)C(O)=O
Gene Information   human ... APP(351)

Description

Amino Acid Sequence

Tyr-Glu-Val-His-His-GlnLys-Leu-Val-Phe-Phe

Biochem/physiol Actions

Amyloid β protein fragment containing the α-secretase processing site (Lys16-Leu17 bond). It also contains the HHQK domain (residues 13-16) responsible for binding to microglial cells. This fragment is also a substrate for matrix metalloproteinase-2 (MMP-2 or gelatinase A).

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
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