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A6987 Sigma-Aldrich

Ceftazidime hydrate

Synonym: 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]pyridinum

  • CAS Number 120618-65-7

  • Empirical Formula (Hill Notation) C22H22N6O7S2 · xH2O

  • Molecular Weight 546.58 (anhydrous basis)

  •  MDL number MFCD00153936

  •  PubChem Substance ID 329770910

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Properties

description   does not contain sodium carbonate
InChI Key   NMVPEQXCMGEDNH-TZVUEUGBSA-N
assay   90.0-105.0% anhydrous basis
form   solid
solubility   0.1 M NaOH: 50 mg/mL
Mode of action   cell wall synthesis | interferes
antibiotic activity spectrum   Gram-negative bacteria
  Gram-positive bacteria
storage temp.   2-8°C

Description

Application

Ceftazidime hydrate is used to study the effect of expression, binding and inhibition of penicillin-binding proteins especially PBP3 on bacterial cell wall mucopeptide synthesis. It is also used in bacterial susceptibility studies and to select mutant colonies of interest.

Biochem/physiol Actions

Cephalosporins, such as ceftazidime , disrupt the synthesis of the peptidoglycan layer of bacterial cell walls.

General description

Broad spectrum antibiotic; third generation cephalosporin

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Safety & Documentation

Safety Information

Symbol 
GHS08  GHS08
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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