EMAIL THIS PAGE TO A FRIEND
A7257 Sigma-Aldrich

(−)-Norepinephrine

≥98%, crystalline

Synonym: (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, L-Arterenol, L-Noradrenaline, Levarterenol

  • CAS Number 51-41-2

  • Empirical Formula (Hill Notation) C8H11NO3

  • Molecular Weight 169.18

  •  Beilstein Registry Number 2804840

  •  EC Number 200-096-6

  •  MDL number MFCD00025592

  •  PubChem Substance ID 24891196

Purchase

Properties

Related Categories Adrenergics, Adrenergics - Agonists, Agonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   SFLSHLFXELFNJZ-QMMMGPOBSA-N
assay   ≥98%
form   crystalline
color   off-white to tan
storage temp.   −20°C
Gene Information   human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)
rat ... Adra1a(29412), Adra1d(29413), Adra2a(25083), Adrb1(24925), Adrb2(24176), Drd1a(24316), Drd2(24318)

Description

Biochem/physiol Actions

Adrenergic neurotransmitter

Packaging

1, 5 g in poly bottle

500 mg in poly bottle

Application

Norepinephrine is an adrenergic neurotransmitter used in the treatment of hypotension, depression, schizophrenia, and attention deficit/hyperactivity disorders.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGII
WGK Germany 
3
RTECS 
DN5950000

Documents

Certificate of Analysis

Certificate of Origin

Frequently Asked Questions

Which document(s) contains shelf-life or expiration date information for a given product?
If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.
How do I get lot-specific information or a Certificate of Analysis?
The lot specific COA document can be found by entering the lot number above under the "Documents" section.
How should Product A7257,(-)-Norepinephrine, be dissolved?
This product is soluble in 0.5M HCl at a concentration of 50mg/mL, yielding a clear faint yellow solution.
What are the differences between Product No. A7257, (-)-Norepinephrine and Product No. A0937, (±)-Norepinephrine (+)-bitartrate salt?
Product No. A7257, is the free base form of the (-) isomer; it is not water soluble. Product No. A0937 is the bitartrate salt of the racemic (+/-) mixture; it is soluble in water at a concentration of 50 mg/mL.
How long is a solution of Product A7257, (-)-Norepinephrine, stable?
A stock solution of 1 mg/ml or greater may be stored frozen in aliquots. Avoid freeze-thaw cycles. When the solution gets a pink cast, the product has degraded.
How do I find price and availability?
There are several ways to find pricing and availability for our products.Once you log onto our website, you will find the price and availability displayed on the product detail page.You can contact any of our Customer Sales and Service offices to receive a quote. USA customers: 1-800-325-3010 orview local office numbers.
What is the Department of Transportation shipping information for this product?
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
My question is not addressed here, how can I contact Technical Service for assistance?
Ask a Scientist here.
Show more questions

Same Products - New Packaging
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Neuroscience

The nervous system, comprised of the brain and spinal cord (central nervous system, or CNS) and network of nerves that connects the CNS to the rest of the body (peripheral nervous system, or PNS) is ...
Keywords: Bioactive small molecules, Central Nervous System, Diseases, Metabolism, Neurodegenerative Diseases, Neuroscience, Neurotransmission, Neurotransmitters

HPLC Analysis of Biogenic Amines on Ascentis® Si, HILIC Mode, (90 %Acetonitrile)

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Biogenic Amines on Ascentis® Si, HILIC Mode, (90 %Acetonitrile)
Keywords: Chromatography, Clinical, High performance liquid chromatography

History of Biogenic Amine Use for Treating Obesity

The discovery of ephedrine (Product No. E2750) in the 1930s led to the synthesis of amphetamines. Initially utilized as stimulants, they were soon shown to exhibit food intake and appetite suppressin...
Keywords: Obesity

LC/MS/MS Analysis of Epinephrine, Metanephrine and Metabolites on Ascentis® Express OH5

From our library of Articles, Sigma-Aldrich presents LC/MS/MS Analysis of Epinephrine, Metanephrine and Metabolites on Ascentis® Express OH5
Keywords: Chromatography, Clinical, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Neurotransmitters, Separation, Solvents

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

UHPLC Analysis of Catecholamines on Ascentis® Express F5

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Catecholamines on Ascentis® Express F5
Keywords: Chromatography, Clinical

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?