A7469 Sigma-Aldrich


from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 98.5-101.0%

Synonym: (S)-2-Aminopropionic acid, L-α-Aminopropionic acid

  • CAS Number 56-41-7

  • Empirical Formula (Hill Notation) C3H7NO2

  • Molecular Weight 89.09

  •  Beilstein/REAXYS Number 1720248

  •  EC Number 200-273-8

  •  MDL number MFCD00064410

  •  eCl@ss 32160406

  •  PubChem Substance ID 24891241

  •  NACRES NA.26



Related Categories Alanine, Amino Acids, Amino Acids & Derivatives, Amino Acids & Vitamins, Amino Acids and Vitamins,
Quality Level   200
biological source   non-animal source
assay   98.5-101.0%
form   powder
application(s)   cell culture | mammalian: suitable
  peptide synthesis: suitable
impurities   endotoxin, tested
color   white
solubility   H2O: 100 mg/mL
suitability   meets EP, USP testing specifications
Featured Industry   Pharmaceutical (small molecule)
SMILES string   C[C@H](N)C(O)=O
InChI   1S/C3H7NO2/c1-2(4)3(5)6/h2H,4H2,1H3,(H,5,6)/t2-/m0/s1
Gene Information   human ... CA1(759), CA2(760)



L-Alanine has been used for tissue culture technique as a media component. It has been used as a media component for the growth of adult mouse keratinocytes.


1 kg in poly bottle

10 mg in glass bottle

25, 100 g in poly bottle

Biochem/physiol Actions

L-Alanine is a nonessential amino acid, which is highly concentrated in muscle. It is a key player in the Glucose-Alanine cycle, which enables the removal of pyruvate and glutamate from muscle to the liver. Once in the liver, glucose is regenerated from pyruvate and returned to the muscle while glutamate ultimately participates in the urea cycle to form urea. The Glucose-Alanine cycle aides to conserve ATP in muscle for muscle contraction, while the energy burden of gluconeogenesis is imposed upon the liver. Alanine inhibits pyruvate kinase to regulate gluconeogenesis and glycolysis in order to maintain glucose homeostasis during starvation. Alanine prevents hepatic autophagy. Alanine formation is a result of transamination of glutamate and pyruvate.

Safety & Documentation

Safety Information

Personal Protective Equipment 
NONH for all modes of transport
WGK Germany 
Protocols & Articles


Glutamine Metabolism is Dysregulated in Many Cancer Cells

Proliferatively active cells require both a source of carbon and of nitrogen for the synthesis of macromolecules. Although a large proportion of tumor cells utilize aerobic glycolysis and shunt metab...
BioFiles v7 n4
Keywords: Aerobic, Cancer, Citric Acid Cycle, Gene expression, Glycolysis, Metabolism, Metabolites, Phosphorylations, Transcription

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Peer-Reviewed Papers


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