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A8206 Sigma-Aldrich

Acacetin

Synonym: 4′-Methylapigenin, 5,7-Dihydroxy-4′-methoxyflavone, Apigenin 4′-methyl ether, Buddleoflavonol, Linarigenin

  • CAS Number 480-44-4

  • Empirical Formula (Hill Notation) C16H12O5

  • Molecular Weight 284.26

  •  Beilstein/REAXYS Number 277879

  •  EC Number 207-552-3

  •  MDL number MFCD00016936

  •  PubChem Substance ID 329770950

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Properties

Related Categories Bioflavonoids, Cell Biology, Nutrition Research, Phytochemicals by Chemical Classification
mp   260-265 °C (lit.)
storage temp.   2-8°C
SMILES string   COc1ccc(cc1)C2=CC(=O)c3c(O)cc(O)cc3O2
InChI   1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3
InChI key   DANYIYRPLHHOCZ-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Flavonoid with anti-peroxidative and anti-inflammatory properties. Used in traditional Chinese medicine. It has been recognized as an antiproliferative agent on cancer cell lines by inducing apoptosis and blocking cell cycle progression in the G1 phase.

A flavonoid derivative possessing antioxidant properties. Induces cell cycle arrest and apoptosis in a time- and dose-dependent manner in several cancer cell lines in vitro.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
DJ3002000

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.1 During the oxi...
Biofiles Volume 2 Article 2
Keywords: Adhesion, Anti-inflammatory agents, Applications, Cancer, Cardiovascular, Catalysis, Diabetes, Diseases, Gene expression, Metabolism, Neurodegenerative Diseases, Peroxidations, Phosphorylations, Prebiotics, Probiotics, Reductions, Transcription, Transduction, Vitamins

Peer-Reviewed Papers
15

References

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Description

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00017 Acacetin, ≥97.0% (HPLC)

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