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A8381 Sigma-Aldrich

L-Asparagine monohydrate

≥99% (TLC)

Synonym: (S)-2-Aminosuccinic acid 4-amide, (S)-(+)-2-Aminosuccinamic acid, L-Aspartic acid 4-amide

  • CAS Number 5794-13-8

  • Linear Formula NH2COCH2CH(NH2)COOH · H2O

  • Molecular Weight 150.13

  •  Beilstein/REAXYS Number 1723527

  •  EC Number 200-735-9

  •  MDL number MFCD00151038

  •  PubChem Substance ID 24891338



General description

Asparagine biosynthesis is catalyzed by glutamine-dependent asparagine synthetase in mammalian tissues. Elevated levels of free asparagine is observed in plants facing stress in the form of drought or high salt. It is also present in senescing leaves and germinating seeds.


L-Asparagine monohydrate has been used:
• as a component of Sauton’s and chelated Sauton’s media for mycobacterial growth
• to test its effect in the induction of Ca2+ flux in rice roots using aequorin luminescence imaging
• as a component of fermentation medium for the Blakeslea trispora spores


1 kg in poly bottle

100 g in poly bottle

Biochem/physiol Actions

Asparagine has high nitrogen to carbon ratio and is a key regulator for nitrogen storage and transport. Its thermal degradation in the presence of sugars leads to the acrylamide formation in foods. Asparagine serves as an amino acid exchange factor and is essential for amino acid homeostasis. It favors cancer cell proliferation.

L-Asparagine, a proteinogenic amino acid, is used in biomanufacturing cell culture systems for the production of therapeutic recombinant proteins and monoclonal antibodies and in cell culture based research.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis


Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles

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