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  • A8476 - 17-(Allylamino)-17-demethoxygeldanamycin

A8476 Sigma-Aldrich


≥98% (HPLC), solid

Synonym: 17-(Allylamino)geldanamycin, 17-Demethoxy-17-allylamino geldanamycin, 17-AAG, CP 127374, Geldanamycin,17-demethoxy-17-(2-propenylamino)-, NSC 330507, Tanespimycin



Related Categories A-AM, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action, Antitumor Agents,
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: soluble
  methanol: soluble
Mode of action   enzyme | inhibits
antibiotic activity spectrum   neoplastics
shipped in   wet ice
storage temp.   −20°C


General description

Chemical structure: benzenoid


17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.


500 μg in glass bottle

Biochem/physiol Actions

Potent inhibitor of heat shock protein 90 (Hsp90). 17-AAG is a less toxic analog than geldanamycin. It induces apoptosis and displays antitumor effects. 17-AAG inhibits the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

Safety & Documentation

Safety Information

NONH for all modes of transport
WGK Germany 


Certificate of Analysis


Certificate of Origin


Milli-Q® Water Purification Solutions
Protocols & Articles


Discover Bioactive Small Molecules for Apoptosis

Apoptosis, or programmed cell death (PCD), is a selective process for the removal of unnecessary, infected or transformed cells in various biological systems. As it plays a role in the homeostasis of...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Clinical, Diseases, Ligands, Neurodegenerative Diseases

Discover Bioactive Small Molecules for Cell Cycle Research

In proliferating cells, the cell cycle consists of four phases. Gap 1 (G1) is the interval between mitosis and DNA replication that is characterized by cell growth. Replication of DNA occurs during t...
Keywords: Apoptosis, Bioactive small molecules, Cancer, Cell division, Cell proliferation, DNA replication, Diseases, Genetic

HPLC Analysis of Geldanamycin and 17-(Allylamino)-17-demethoxy geldanamycin on Ascentis® Express C18

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Geldanamycin and 17-(Allylamino)-17-demethoxy geldanamycin on Ascentis® Express C18
Keywords: Antibiotics, Chromatography, Clinical, High performance liquid chromatography, Separation, Solvents

Oncogenes and Tumor Suppressors Reprogram Metabolism

Proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication. This requires a reprogramming of the metabolic pathways to ensure nutrients s...
Keywords: Aerobic, Antitumor agents, Apoptosis, Biofiles, Cancer, Citric Acid Cycle, Degradations, Environmental, Events, Gene expression, Glycolysis, Growth factors, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Phosphorylations, Support

Peer-Reviewed Papers


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