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A8626 Sigma-Aldrich

Adenine

≥99%

Synonym: 6-Aminopurine, Vitamin B4

  • CAS Number 73-24-5

  • Empirical Formula (Hill Notation) C5H5N5

  • Molecular Weight 135.13

  •  Beilstein/REAXYS Number 5777

  •  EC Number 200-796-1

  •  MDL number MFCD00041790

  •  PubChem Substance ID 24891349

  •  NACRES NA.51

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Properties

Related Categories Artemisia vulgaris, Biochemicals and Reagents, Cell Biology, Nutrition Research, Panax ginseng,
biological source   synthetic
InChI Key   GFFGJBXGBJISGV-UHFFFAOYSA-N
assay   ≥99%
form   powder
application(s)   UV/Vis spectroscopy: suitable
color   white to off-white
mp   >360 °C (lit.)
solubility   0.5 M HCl: soluble 20 mg/mL, Grade III, colorless to faint yellow or tan
storage temp.   room temp
Gene Information   human ... AKT1(207), GSK3B(2932), LCK(3932), MAP3K1(4214), MAPK14(1432), MAPK8(5599), MAPK9(5601), MAPKAPK2(9261), PRKACA(5566), PRKCA(5578), RAF1(5894), ROCK2(9475)
mouse ... Mapk1(26413)
rat ... Camk2a(25400), Mapk10(25272)

Description

General description

Adenine is a purine nucleobase. It is part of DNA, and RNA.

Application

Adenine is suitable for use:
• as a component of boron-deficient media to grow yeast in order to assess whether yeast growth is stimulated by boron
• as a food supplement for adult rats to investigate the effects of dietary adenine overload
• as a nucleic acid base supplement in the basal media used to grow anaerobic Bacillus mojavensis and Bacillus subtilis in a study to show that DNA or deoxyribonucleosides are required for the anaerobic growth of these bacteria
• as an additive to investigate the effects of adenine on CH4 production and on fermentation by ruminal batch cultures from nonlactating Holstein cows
• as a part of adenine diet in rats in a study to identify blood markers for early stages of adenine-induced chronic kidney disease (CKD)

Packaging

1 kg in poly bottle

1, 5, 25, 100 g in poly bottle

Biochem/physiol Actions

Adenine is essential for many biochemical processes. Adenine is converted to adenosine with ribose. On phosphorylation, it forms AMP, ADP and ATP. ATP is the energy currency of the cell and is required during cellular metabolism. Adenine is metabolized to is 2,8-dihydroxyadenine, which on accumulation in proximal tubules leads to the induction of chronic kidney disease (CKD) with severe anemia in rats. Adenine based derivatives elicit antiviral functionality against dsDNA viruses and are exploited for generating antiviral scaffolds.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
RTECS 
AU6125000
Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Related Content

Indoles, Purines, and Their Isosteres

Substituted indoles and purines have frequently been referred to as “privileged structures” since they are capable of binding to multiple receptors with high affinity, and thus have applications acro...
Keywords: Building blocks, Medicinal chemistry

Peer-Reviewed Papers
15

References

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