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A8986 Sigma-Aldrich

Alexidine dihydrochloride

≥95% (HPLC)

Synonym: 1,1′-Hexamethylene-bis(5-[2-ethylhexyl]biguanide)

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Properties

Related Categories A-AM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology
InChI Key   BRJJFBHTDVWTCJ-UHFFFAOYSA-N
assay   ≥95% (HPLC)
form   powder
color   white to off-white
solubility   DMSO: ≥10 mg/mL
storage temp.   −20°C

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Alexidine dihydrochloride is a potent and selective PTPMT1 (Protein Tyrosine Phosphatase Localized to the Mitochondrion 1) inhibitor. Alexidine increases insulin secretion by isolated rat pancreatic islets.

Features and Benefits

This compound is featured on the Phosphoprotein Phosphatases (Tyrosine) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Phosphoprotein Phosphatases (Tyrosine)

Protein tyrosine phosphatases (PTPs) and related enzymes (more than a hundred coded by the human genome) are more numerous than serine/threonine phosphatases. They belong to four families, three of w...
Keywords: Adhesion, Cancer, Catalysis, Diabetes, Gene expression, Ligands, Phosphorylations

Peer-Reviewed Papers
15

References

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