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A9101 Sigma-Aldrich

Acetylcholine chloride

pkg of 150 mg (per vial)

Synonym: ACh

  • CAS Number 60-31-1

  • Linear Formula (CH3)3N+CH2CH2OCOCH3Cl-

  • Molecular Weight 181.66

  •  Beilstein Registry Number 3571875

  •  EC Number 200-468-8

  •  MDL number MFCD00011698

  •  PubChem Substance ID 57653883

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Properties

Related Categories Activity, Analytical and Industrial Enzymes, Biochemicals and Reagents, Cholinesterase Substrates, Cholinesterase and Organophosphate Detection Reagents,
InChI Key   JUGOREOARAHOCO-UHFFFAOYSA-M
assay   ≥99% (TLC)
packaging   pkg of 150 mg (per vial)
mp   146-150 °C (lit.)
solubility   H2O: soluble
storage temp.   room temp

Description

Reconstitution

Reconstituted solution is stable for 2 weeks when stored at 2-8 °C

Application

For use as a substrate to determine acetylcholinesterase activity. Acetylcholine chloride has been used:
• for standard curve preparation in hestrin assay
• in Protein expression, radioactive ligand binding assay and electrophysiological studies of Lymnaea stagnalis acetylcholine binding protein (Ls-AChBPs)
• as a supplement in extracellular solutions for treating the voltage clamped cells in electrophysiology studies

Biochem/physiol Actions

Acetyl choline (ACh) is an essential neurotransmitter in both central and peripheral nervous system. ACh binds to nicotinic acetylcholine receptors (nAChRs) and causes fast excitatory neurotransmission.

Acetylcholine chloride, injected at 20 mg/kg body weight, reduces mortality and plasma proinflammatory cytokines in mice with experimentally-induced sepsis . The cholinergic anti-inflammatory mechanism is probably mediated by interaction of acetylcholine with α7n cholinoreceptor on monocytes, macrophages, and neutrophils, which decreases the levels of proinflammatory cytokines such as TNF-α, IL-1β, and IL-6.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
FZ9800000
Protocols & Articles
Peer-Reviewed Papers
15

References

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