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A9519 Sigma-Aldrich

N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate

≥98% (TLC)

Synonym: Adjuvant Peptide, Muramyl dipeptide

  • CAS Number 53678-77-6

  • Empirical Formula (Hill Notation) C19H32N4O11 · xH2O

  • Molecular Weight 492.48 (anhydrous basis)

  •  Beilstein/REAXYS Number 4220745

  •  EC Number 258-696-9

  •  MDL number MFCD00077638

  •  PubChem Substance ID 24891464

  •  NACRES NA.26

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Properties

Related Categories Bacteria-derived adjuvants, Cell Biology, Cell Culture, Cell Signaling and Neuroscience, Other Peptides,
InChI Key   BSOQXXWZTUDTEL-QAQREVAFSA-N
assay   ≥98% (TLC)
storage temp.   −20°C

Description

Amino Acid Sequence

MurNAc-Ala-Agn

Application

N-Acetylmuramyl-L-alanyl-D-isoglutamine hydrate has been used in staphylococcal cell wall preparation to induce the release of TNF from human monocytes.

Biochem/physiol Actions

Enhances antigenicity of weak antigens, increasing antibody titer.

Muramyl peptides are monomeric components that make up the bacterial cell wall peptidoglycan. It is generally produced by mammalian macrophages, as an immune response in the breakdown of bacterial cell wall. MDP promotes the production of interleukin-1 and tumor necrosis factor (TNF), which increase slow-wave sleep.

N-Acetylmuramyl-L-alanyl-D-isoglutamine (MDP, muramyl dipeptide), a neurotrophic and immunomodulatory factor related to bacterial peptidoglycans, is used as an immune modulation factor that enhances immune response and to study neural development.

Enhances antigenicity of weak antigens, increasing antibody titer.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
MA2275260

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Pipette Controller from Brand
Protocols & Articles

Articles

Choosing the optimal vaccine adjuvant

The word "vaccination" was first coined by English scientist Edward Jenner in 1796, although early forms of vaccination have been documented as far back as the 17th century.1 Vaccination is used to g...
BioFiles Vol. 5, No. 3
Keywords: Cancer, Clinical, Diseases, Inflammation, Veterinary

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Peer-Reviewed Papers
15

References

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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