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B112 Sigma-Aldrich

(±)-Bay K8644

calcium channel agonist

Synonym: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-(2-[trifluoromethyl]phenyl)pyridine-3-carboxylic acid methyl ester

  • CAS Number 71145-03-4

  • Empirical Formula (Hill Notation) C16H15F3N2O4

  • Molecular Weight 356.30

  •  MDL number MFCD00036697

  •  PubChem Substance ID 24277825

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Properties

Related Categories Biochemicals and Reagents, Calcium Channel Modulators, Cell Biology, Cell Signaling and Neuroscience, Enzyme Inhibitors,
InChI Key   ZFLWDHHVRRZMEI-UHFFFAOYSA-N
solubility   DMSO: 20 mg/mL
  methanol and ethanol: 63 mg/mL
  H2O: insoluble
storage temp.   2-8°C
Gene Information   rat ... Cacna1c(24239)

Description

Application

(±)-Bay K8644 has been used as an agonist for voltage sensitive calcium channels (VSCCs) in interneurons, L-type calcium channel (LTCC) in human embryonic kidney 293 cells and viscerofugal neurons.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

(±)-Bay K8644 is a 1,4-dihydropyridine (DHP) derivative and an agonist for L-type Ca2+ channels. However, it′s enantiomers (-)-BAY k8644 and (+)-BAY k8644 have opposing functionality with respect to Ca2+ channels as high-potency agonist and low-potency antagonist, respectively. (±)-Bay K8644 increases influx of Ca2+ specifically at voltage-gated calcium channels. It constricts blood vessels and heart contraction.

Increases influx of Ca2+ specifically at voltage-gated calcium channels.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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