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  • B2311 - 5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide

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B2311 Sigma-Aldrich

5-(2-Benzothiazolyl)-3-ethyl-2-[2-(methylphenylamino)ethenyl]-1-phenyl-1H-benzimidazolium iodide

≥98% (HPLC)

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Properties

Related Categories B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
InChI Key   NAYRELMNTQSBIN-UHFFFAOYSA-M
assay   ≥98% (HPLC)
form   powder
color   yellow to orange
solubility   DMSO: 5 mg/mL, clear
storage temp.   2-8°C

Description

Packaging

5 mg in glass bottle

Biochem/physiol Actions

5-(2-Benzothiazolyl)-3-et<WBR>hyl-2-[2-(methylphenylami<WBR>no)-ethenyl]-1-phenyl-1H-<WBR>benzimidazolium, or Akt Inhibitor IV, is a cell-permeable benzimidazole compound that inhibits Akt phosphorylation/activatio<WBR>n by targeting the ATP binding site of a kinase upstream of Akt, but downstream of PI3K. Shown to block Akt-mediated FOXO1a nuclear export (IC<SUB>50</SUB> = 0.625μM) and cell proliferation (IC<SUB>50</SUB> < 1.25μM) in 786-O cells. Unlike phosphatidylinositol analog-based Akt inhibitors, this inhibitor does not affect PI3K.

Features and Benefits

This compound is featured on the PKB/Akt page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Oncogenes and Tumor Suppressors Reprogram Metabolism

Proliferating cells require the biosynthesis of structural components for biomass production and for genomic replication. This requires a reprogramming of the metabolic pathways to ensure nutrients s...
Keywords: Aerobic, Antitumor agents, Apoptosis, Biofiles, Cancer, Citric Acid Cycle, Degradations, Environmental, Events, Gene expression, Glycolysis, Growth factors, Metabolic Pathways, Metabolism, Metabolites, Nucleotide Synthesis, PAGE, Pentose phosphate pathway, Phosphorylations, Support

PKB/Akt

The PDK1–PKB/Akt axis represents one of the most actively researched cell signaling pathways. This protein kinase cascade is known to play a central role in mediating the actions of a range of stimul...
Keywords: Apoptosis, Atomic absorption spectroscopy, Cancer, Cell proliferation, Cell signaling, Diabetes, Gene expression, Growth factors, Inflammation, Metabolism, Myristoylations, Phosphorylations, Reversible addition-fragmentation chain transfer polymerizations

Peer-Reviewed Papers
15

References

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