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B3061 Sigma-Aldrich

Borrelidin

from Streptomyces parvulus, ≥98% (HPLC)

Synonym: 2-(7-Cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)-cyclopentanecarboxylic acid, Borrelidine, Cyclopentanecarboxylic acid, NSC 216128, Treponemycin

  • CAS Number 7184-60-3

  • Empirical Formula (Hill Notation) C28H43NO6

  • Molecular Weight 489.64

  •  MDL number MFCD01740784

  •  PubChem Substance ID 24724417

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
biological source   Streptomyces parvulus
InChI Key   OJCKRNPLOZHAOU-UGKRXNSESA-N
assay   ≥98% (HPLC)
solubility   DMSO: 1 mg/mL
  methanol: 1 mg/mL
Mode of action   enzyme | inhibits
antibiotic activity spectrum   viruses
shipped in   wet ice
storage temp.   −20°C

Description

General description

Chemical structure: macrolide

Biochem/physiol Actions

Borrelidin is a potent angiogenesis inhibitor that induces apoptosis in capillary tube-forming cells. Also displays antimalarial activity against drug-resistant Plasmodia. Antimicrobial and selective threonyl t-RNA synthetase inhibitor.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
ED8750000

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles
Peer-Reviewed Papers
15

References

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