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B3806 Sigma-Aldrich

Bisindolylmaleimide VIII acetate salt

≥93% (H-NMR)

Synonym: Ro 31-7549 acetate

  • CAS Number 138516-31-1

  • Empirical Formula (Hill Notation) C24H22N4O2 · C2H4O2

  • Molecular Weight 458.51

  •  MDL number MFCD00909467

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Properties

assay   ≥93% (H-NMR)
solubility   DMSO: soluble
  H2O: soluble
  methanol: soluble
storage temp.   −20°C
SMILES string   CC(O)=O.Cn1cc(C2=C(C(=O)NC2=O)c3cn(CCCN)c4ccccc34)c5ccccc15
InChI   1S/C24H22N4O2.C2H4O2/c1-27-13-17(15-7-2-4-9-19(15)27)21-22(24(30)26-23(21)29)18-14-28(12-6-11-25)20-10-5-3-8-16(18)20;1-2(3)4/h2-5,7-10,13-14H,6,11-12,25H2,1H3,(H,26,29,30);1H3,(H,3,4)
InChI key   VEOXVBTXROWDAH-UHFFFAOYSA-N

Description

Biochem/physiol Actions

Bisindolylmaleimide VIII acetate is a selective inhibitor of protein kinase C (PKC). Bisindolylmaleimide VIII acetate enhances Fas- and TRAIL-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.

Caution

Photosensitive

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
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