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B4063 Sigma-Aldrich

BIMU8 hydrate

≥98% (HPLC)

Synonym: 2,3-Dihydro-N-[(3-endo)-8-methyl-8-azabicyclo[3.2.1]oct-3-yl]-3-(1-methylethyl)-2-oxo-1H-benzimidazole-1-carboxamide Hydrochloride (1:1) hydrate

  • CAS Number 134296-40-5 (anhydrous)

  • Empirical Formula (Hill Notation) C19H26N4O2·HCl · xH2O

  • Molecular Weight 378.90 (anhydrous basis)

  •  PubChem Substance ID 329773228

  •  NACRES NA.77

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Properties

Related Categories Agonists, B, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Biochemicals and Reagents,
assay   ≥98% (HPLC)
storage condition   desiccated
color   off-white to light tan
solubility   H2O: ≥5 mg/mL
storage temp.   2-8°C
InChI   1S/C19H26N4O2.ClH.H2O/c1-12(2)22-16-6-4-5-7-17(16)23(19(22)25)18(24)20-13-10-14-8-9-15(11-13)21(14)3;;/h4-7,12-15H,8-11H2,1-3H3,(H,20,24);1H;1H2/t13-,14+,15-;;
InChI key   HZJJVFOOACXPTH-XZAJHMFNSA-N

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

BIMU8 hydrate is a potent 5-HT4 serotonin receptor agonist. Serotonin (5-HT) is a major neurotransmitter that acts through a family of GPCRs and one ion channel. 5-HT4 receptor is GPCR expressed in many tissues, including brain, and modulates dopamine secretion, learning, and memory. BIMU8 is a full agonist at 5-HT4, but it binds differently than the endogenous ligand, 5-HT, shown through site-directed mutagenesis studies. It depolarizes neurons and was used to localize 5-HT4 to somatic but not dendritic regions of CA1 pyramidal neurons.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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