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B5258 Sigma-Aldrich

N6-Benzoyladenine

≥99%

  • CAS Number 4005-49-6

  • Empirical Formula (Hill Notation) C12H9N5O

  • Molecular Weight 239.23

  •  MDL number MFCD00037927

  •  PubChem Substance ID 24891827

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Properties

Related Categories Biochemicals and Reagents, Nucleoside Analogs, Nucleosides, Nucleotides, Oligonucleotides More...
InChI Key   QQJXZVKXNSFHRI-UHFFFAOYSA-N
assay   ≥99%
storage temp.   2-8°C

Description

Packaging

5, 25 g in poly bottle

Application

N6-Benzoyladenine is used in the organic synthesis of adenine derivative molecules such as bicyclic adenine nucleoside via a condensation reaction between L-threo-pentofuranose derivative 1 and 6-N-benzoyladenine and to produce oxy-peptide nucleic acids.

Biochem/physiol Actions

N6-Benzoyladenine comprises of adenine moiety and is a potent inhibitor of bromodomain-containing protein 4 (BRD4). N6-Benzoyladenine modulates tumor necrosis factor α (TNF-α) levels. It elicits cytotoxicity in liver and ileum cancer cells and may serve as a potential candidate agent for cancer chemotherapy.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
Protocols & Articles
Peer-Reviewed Papers
15

References

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