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B5416 Sigma-Aldrich

8-Bromo-cyclic adenosine diphosphate ribose

85% (HPLC), lyophilized powder

Synonym: Br-cADP-ribose, Br-cADPR

  • CAS Number 151898-26-9

  • Empirical Formula (Hill Notation) C15H20BrN5O13P2

  • Molecular Weight 620.20

  •  MDL number MFCD00274402

  •  eCl@ss 32160414

  •  PubChem Substance ID 329773258

  •  NACRES NA.51

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Properties

Related Categories Cell Biology, Cell Signaling and Neuroscience, Intracellular Calcium Regulators, Intracellular Calcium Signaling
Quality Level   200
assay   85% (HPLC)
form   lyophilized powder
color   white
solubility   H2O: 5 mg/mL
storage temp.   −20°C
SMILES string   Nc1ncnc2n([C@@H]3O[C@@H]4COP(O)(=O)OP(=O)(O[C@@H]5O[C@H](CO)[C@@H](O)[C@H]5O)O[C@H]4[C@H]3O)c(Br)nc12
InChI   1S/C15H20BrN5O13P2/c16-15-20-6-11(17)18-3-19-12(6)21(15)13-9(25)10-5(30-13)2-29-35(26,27)34-36(28,32-10)33-14-8(24)7(23)4(1-22)31-14/h3-5,7-10,13-14,22-25H,1-2H2,(H,26,27)(H2,17,18,19)/t4-,5-,7-,8-,9-,10-,13-,14+,36?/m1/s1
InChI key   PLQQKRPSINJWTK-VNMBDIRDSA-N

Description

Biochem/physiol Actions

An antagonist of cyclic ADP-ribose (cADPR), and an endogenous metabolite of β-NAD+. cADPR has been shown to regulate calcium release from the endoplasmic and sarcoplasmic reticulum. In cells, cADPR is synthesized by ADP-ribosyl cyclase or CD38, a lymphocyte differentiation antigen.

Physical form

Lyophilized powder containing 10-20% sodium phosphate buffer salts

Preparation Note

Prepared enzymatically

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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