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BM0010 Sigma-Aldrich

Ifetroban sodium

≥98% (HPLC)

Synonym: 2-[[(1S,2R,3S,4R)-3-[4-[(Pentylamino)carbonyl]-2-oxazolyl]-7-oxabicyclo[2.2.1]hept-2-yl]methyl]-benzenepropanoic acid sodium salt, BMS 180291-02, BMS-180291 sodium, Sodium ifetroban

  • CAS Number 156715-37-6

  • Empirical Formula (Hill Notation) C25H31N2O5 · Na

  • Molecular Weight 462.51

  •  PubChem Substance ID 329774354

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Properties

Related Categories Arachidonic Acid Cascade, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: 20 mg/mL, clear
storage temp.   room temp
SMILES string   [O-]C(CCC1=C(C[C@H]2[C@@H](O3)CC[C@@H]3[C@H]2C4=NC(C(NCCCCC)=O)=CO4)C=CC=C1)=O.[Na+]
InChI   1S/C25H32N2O5.Na/c1-2-3-6-13-26-24(30)19-15-31-25(27-19)23-18(20-10-11-21(23)32-20)14-17-8-5-4-7-16(17)9-12-22(28)29;/h4-5,7-8,15,18,20-21,23H,2-3,6,9-14H2,1H3,(H,26,30)(H,28,29);/q;+1/p-1/t18-,20-,21+,23-;/m0./s1
InChI key   WOHSQDNIXPEQAE-QBKVZTCDSA-M

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Ifetroban (BMS-180291) is a potent and selective thromboxane receptor antagonist. The IC50 for inhibition of arachadonate or U-46619-induced platelet aggregation in human plasma is 7 nM and 30 nM, respectively. Ifetroban inhibits platelet aggregation in African green monkey 100% at 3 mpk, and blocks the contractile effects of U-46619 and Ang II in rabbit renal afferent arterioles.

Features and Benefits

Ifetroban is available through a partnership with Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Legal Information

Sold for research purposes only under agreement from BMS.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport

Documents

Certificate of Analysis (COA)

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Protocols & Articles

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