EMAIL THIS PAGE TO A FRIEND
BM0029 Sigma

AM095

≥98% (HPLC)

Synonym: 1,1′-Biphenyl]-4-acetic acid, 4′-[3-methyl-4-[[[(1R)-1-phenylethoxy]carbonyl]amino]-5-isoxazolyl]-, sodium salt (1:1), AM-095, AMI-000533, Sodium {4′-[3-methyl-4-((R)-1-phenyl-ethoxycarbonylamino)-isoxazol-5-yl]-biphenyl-4-yl}-acetate

  • CAS Number 1345614-59-6

  • Empirical Formula (Hill Notation) C27H23N2O5 · Na

  • Molecular Weight 478.47

Purchase

Properties

Related Categories A-AM, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience,
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: 10 mg/mL, clear
storage temp.   room temp

Description

Packaging

5, 25 mg in glass bottle

Legal Information

Sold for research purposes only under agreement from BMS.

Biochem/physiol Actions

AM095 is a potent and selective, orally bioavailable antagonist of lysophosphatidic acid receptor1 (LPA1). AM095 inhibited LPA-driven chemotaxis of CHO cells overexpressing mouse LPA1 and human A2058 melanoma cells. LPA1 has been shown to be involved in neuropathic pain. AM095 inhibition of LPA1 after spinal cord injury resulted in reduced demyelination and improvement in locomotor recovery.

Features and Benefits

AM095 is available through a partnership between Sigma Life Science and Bristol-Myers Squibb (BMS). To learn more and view other BMS compounds, visit sigma.com/BMS.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles

Related Content

Discover Bristol-Myers Squibb Compounds

Sigma® Life Science understands that in your research, the right tools are essential. Our commitment to providing researchers with the broadest selection of reliable, quality-controlled tools has res...
Keywords: Bioactive small molecules, Clinical, Genomics, Immunology, Neuroscience, Research areas

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?


Discover your Target