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C0158 Sigma-Aldrich

L-Carnitine inner salt

synthetic, ≥98%

Synonym: (−)-(R)-3-Hydroxy-4-(trimethylammonio)butyrate, Vitamin BT

  • CAS Number 541-15-1

  • Linear Formula (CH3)3N+CH2CH(OH)CH2COO-

  • Molecular Weight 161.20

  •  Beilstein/REAXYS Number 4292315

  •  EC Number 208-768-0

  •  MDL number MFCD00038747

  •  PubChem Substance ID 24892238

  •  NACRES NA.79

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Properties

Related Categories Cell Biology, Nutrition Research, Other Biochemical, Phytochemicals by Chemical Classification
biological source   synthetic
InChI Key   PHIQHXFUZVPYII-ZCFIWIBFSA-N
assay   ≥98%
mp   197-212 °C (lit.)

Description

Application

L-Carnitine inner salt has been used as a component of an assay medium for Seahorse XF mitochondrial stress assay. It has also been orally administered to tumor-bearing mice, in order to study its effect on the regulation of peroxisome proliferator-activated receptor and thereby to analyse liver inflammatory response.

Packaging

1, 5, 25, 100 g in poly bottle

Biochem/physiol Actions

Carnitine biosynthesized from lysine. Carnitine facilitates fatty acid transport into the mitochondrial compartment. In skeletal and cardiac muscle tissue it acts as a metabolic cofactor. Carnitine might be associated with the energy production from branched chain amino acids.

Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3
RTECS 
BP2980000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles

Articles

Acyl-L-Carnitines

Carnitine was discovered at the beginning of the last century and plays an important role in fatty acid metabolic pathways.1 It acts as a carrier of activated fatty acids across the inner mitochondri...
Keywords: Chromatography, Diseases, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolic Pathways, Metabolism, Separation

HPLC Analysis of Caffeine, Choline, Taurine, Inositol, and Carnitine on SeQuant ZIC-HILIC

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Caffeine, Choline, Taurine, Inositol, and Carnitine on SeQuant ZIC-HILIC
Keywords: High performance liquid chromatography

Peer-Reviewed Papers
15

References

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