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C0283 Sigma-Aldrich

L-Carnitine hydrochloride

synthetic, ≥98%

Synonym: (−)-β-Hydroxy-γ-(trimethylammonio)butyrate, Vitamin BT

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Properties

Related Categories Amino Acid, Cell Biology, Metabolic Pathways, Metabolites and Cofactors on the Metabolic Pathways Chart, Metabolomics,
biological source   synthetic
InChI Key   JXXCENBLGFBQJM-FYZOBXCZSA-N
assay   ≥98%

Description

Application

L-Carnitine hydrochloride has been used to study ergothioneine transporter SLC22A4 and carnitine transporter SLC22A5. It has also been used to allow the entry of palmitic acid into the mitochondria.

Packaging

1, 5, 25, 100 g in poly bottle

10 mg in glass bottle

Biochem/physiol Actions

Carnitine is biosynthesized from lysine. It might be associated with the energy production from branched chain amino acids.

Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. It is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It shifts glucose metabolism from glycolysis to glycogen storage and enhances the transport of long chain fatty acids into the mitochondria where they are oxidized for energy production.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
BP2979100

Documents

Certificate of Analysis

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Certificate of Origin

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Protocols & Articles

Articles

LC/MS Analysis of Fourteen Acyl-L-Carnitines on Ascentis® Express OH5

From our library of Articles, Sigma-Aldrich presents LC/MS Analysis of Fourteen Acyl-L-Carnitines on Ascentis® Express OH5
Keywords: Chromatography, Derivatizations, High performance liquid chromatography, Liquid chromatography mass spectrometry, Mass spectrometry, Metabolism, Separation

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Mitochondrial Dysfunction and Metabolic Defects

Defects in mitochondrial function are associated with insulin resistance in both human and animal studies. Insulin resistance is associated with a decrease in the number, oxidative capacity, size, an...
Keywords: Acetylations, Apoptosis, Biofiles, Cancer, Carboxylations, Catalog, Catalysis, Citric Acid Cycle, Decarboxylations, Degradations, Diabetes, Enzyme-linked immunosorbent assay, Glycolysis, Immunofluorescence, Immunohistochemistry, Lipid Metabolism, Metabolism, Metabolites, Neurotransmitters, Obesity, Oxidations, Phosphorylations, Physiological Processes, Protocols, Transcription, Transduction, Transfection, Western blot

Peer-Reviewed Papers
15

References

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