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C0289 Sigma-Aldrich

Cholesteryl linoleate

≥98% (HPLC; detection at 205 nm)

Synonym: 3β-Hydroxy-5-cholestene 3-linoleate, 5-Cholesten-3β-ol 3-linoleate, Cholesteryl 9,12-octadecadienoate, Cholesteryl octadecadienoate

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cholesterol and Derivatives, Lipids, Metabolic Pathways,
InChI Key   NAACPBBQTFFYQB-LJAITQKLSA-N
assay   ≥98% (HPLC; detection at 205 nm)
storage temp.   −20°C

Description

Application

Cholesteryl linoleate was cosonicated with cholesterol to prepare dispersions were prepared to study the cholesterol to phospholipid ratio in red blood cell membrane. It was used as HPLC standard in the analysis of rat liver lipoproteins.

Packaging

1 g in ampule

100, 250 mg in ampule

Biochem/physiol Actions

Cholesteryl linoleate is a major cholesterol ester found associated with the neutral core of low density lipoprotein. Receptor-LDL complexes are taken up by lysosomes and hydrolyzed to release cholesterol from the esters. The enzyme acid cholesteryl ester hydrolase is responsible for the hydrolysis of cholesteryl esters; a defective enzyme can result in the formation of atherosclerotic lesions in humans.

The most abundant cholesteryl ester in low density lipoprotein (LDL).

Packaging

Sealed ampule

Preparation Note

Cholesteryl linoleate yields clear, colorless solution in chloroform at 100 mg/ml.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3
Flash Point(F) 
>235.4 °F
Flash Point(C) 
>113 °C

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

BACSMLS Online Plate Map

BACSMLS compounds are conveniently provided at 5µg per well, enough for multiple injections. These are high purity (>95%) compounds supplied in an economical, ready to use format. Compounds are arran...
Keywords: Metabolites

Cholesterol Esterification

To more efficiently transport both dietary and synthesized cholesterol, it is converted to cholesteryl esters. Free cholesterol can be taken up by lipoproteins, but is confined to the outer surface o...
BioFiles 2007, 2.7, 10.
Keywords: Biofiles, Catalysis

TLC Analysis of Cholesteryl Esters on HPTLC Silica Gel 60 F 254 with Concentrating Zone (analyte set 2)

From our library of Articles, Sigma-Aldrich presents TLC Analysis of Cholesteryl Esters on HPTLC Silica Gel 60 F 254 with Concentrating Zone (analyte set 2)
Keywords: Thin layer chromatography

Peer-Reviewed Papers
15

References

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Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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