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C1119 Sigma-Aldrich

Caroverine hydrochloride

≥98% (HPLC), solid

Synonym: 1-[2-(Diethylamino)ethyl]-3-[(4-methoxyphenyl)methyl]-2(1H)-quinoxalinone monohydrochloride

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Properties

Related Categories AMPA/Kainate Antagonists, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH, Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
solubility   DMSO: >10 mg/mL
  H2O: insoluble
storage temp.   2-8°C
SMILES string   Cl.CCN(CC)CCN1C(=O)C(Cc2ccc(OC)cc2)=Nc3ccccc13
InChI   1S/C22H27N3O2.ClH/c1-4-24(5-2)14-15-25-21-9-7-6-8-19(21)23-20(22(25)26)16-17-10-12-18(27-3)13-11-17;/h6-13H,4-5,14-16H2,1-3H3;1H
InChI key   JRNWTJUIMRLKBV-UHFFFAOYSA-N

Description

Packaging

10, 50 mg in glass bottle

Biochem/physiol Actions

Caroverine hydrochloride is a nonselective NMDA and AMPA glutamate receptor antagonist. Also, Caroverine hydrochloride is a class B calcium-channel-blocker, antiglutamatergic agent, and acts as an antioxidant when administered to lab animals.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Glutamate Receptors (Ion Channel Family)

The ion channel family of glutamate receptors ("€œionotropic"€ glutamate receptors or iGluR) comprises three major subtypes based on pharmacology and protein structure.
Keywords: Alzheimer Disease, Anticonvulsants, Atomic absorption spectroscopy, Clinical, Gene expression, Ligands, Neurotransmission, Physiological Processes, Schizophrenia

Peer-Reviewed Papers
15

References

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