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C1244 Sigma-Aldrich

CHM-1 hydrate

≥99% (HPLC), solid

Synonym: 2-(2-fluorophenyl)-6,7-methylenedioxy-2-4-quinolone hydrate, NSC 656158

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Properties

Related Categories Apoptosis Inducers, Apoptosis and Cell Cycle, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, C-CH,
InChI Key   KIAVGSCBJYDTIM-UHFFFAOYSA-N
assay   ≥99% (HPLC)
form   solid
storage condition   desiccated
solubility   DMSO: ≥5 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

CHM-1 possess antimitotic antitumor activity. It is a potent and selective antitumor agent in human hepatocellular carcinoma. CHM-1 induces apoptosis, and it binds tubulin and inhibits tubulin polymerization.

Features and Benefits

This compound is featured on the CDKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

CDKs

Cyclin dependent kinases (CDKs) are typical serine/threonine kinases that display the 11 subdomains shared by all kinases. The complete sequence of the Homo sapiens genome shows that among the ~30,00...
Keywords: Alzheimer Disease, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Catalysis, DNA replication, Diseases, Gene expression, Parkinson Disease, Phosphorylations, Transcription

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