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C126 Sigma-Aldrich

S-(−)-Carbidopa

>98%, solid

Synonym: (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid, S-(−)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid

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Properties

InChI Key   TZFNLOMSOLWIDK-JTQLQIEISA-N
assay   >98%
form   solid
optical activity   [α]26/D −13.82°, c = 0.3 in methanol(lit.)
color   white
εmax   2950 at 282.5 nm in methanol
storage temp.   −20°C
Gene Information   human ... DDC(1644)

Description

Biochem/physiol Actions

Peripheral inhibitor of L-aromatic amino acid decarboxylase. When co-administered with L-DOPA, it prevents extra-CNS conversion to dopamine, thereby increasing CNS concentrations of effective compounds. Selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells by increasing H2O2 in these cell lines, which are sensitive to reactive oxygen species.

Caution

Light sensitive

Safety & Documentation

Safety Information

WGK Germany 
3
RTECS 
MW5298000

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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