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C1335 Sigma-Aldrich

S-(−)-Carbidopa

≥98% (TLC), powder

Synonym: (S)-3-(3,4-Dihydroxyphenyl)-2-hydrazino-2-methylpropanoic acid, S-(−)-α-Hydrazino-3,4-dihydroxy-2-methylbenzenepropanoic acid

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Properties

Related Categories A to C, Aromatic L-amino acid decarboxylase inhibitor, Biochemicals and Reagents, Enzyme Inhibitors, Enzyme Inhibitors by Enzyme,
Quality Level   200
assay   ≥98% (TLC)
form   powder
solubility   methanol and 1 drop HCl: 4.90-5.10 mg/mL, clear, colorless to faintly yellow
storage temp.   −20°C
SMILES string   CC(Cc1ccc(O)c(O)c1)(NN)C(O)=O
InChI   1S/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/m0/s1
InChI key   TZFNLOMSOLWIDK-JTQLQIEISA-N
Gene Information   human ... DDC(1644)

Description

General description

Carbidopa is used for treating restless legs (RL) syndrome and periodic leg movements in sleep (PLMS). Carbidopa along with levodopa is used to treat Parkinson′s disease.

Packaging

100 mg in glass bottle

25 mg in poly bottle

Biochem/physiol Actions

Peripheral inhibitor of L-aromatic amino acid decarboxylase. When co-administered with L-DOPA, it prevents extra-CNS conversion to dopamine, thereby increasing CNS concentrations of effective compounds. Selectively cytotoxic to human pulmonary carcinoid and small cell lung carcinoma cells by increasing H2O2 in these cell lines, which are sensitive to reactive oxygen species.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
MW5298000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Dopa and Carbidopa Enantiomers on Astec® CHIROBIOTIC® T2

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Dopa and Carbidopa Enantiomers on Astec® CHIROBIOTIC® T2
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

HPLC Analysis of Dopa and Carbidopa Enantiomers on Astec® CHIROBIOTIC® T

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Dopa and Carbidopa Enantiomers on Astec® CHIROBIOTIC® T
Keywords: Chromatography, Clinical, Forensic, High performance liquid chromatography, Pharmaceutical

Peer-Reviewed Papers
15

References

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