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C171 Supelco

Clozapine

solid

Synonym: 8-Chloro-11-(4-methyl-1-piperazinyl)-5H-dibenzo[b,e][1,4]-diazepine

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Properties

form   neat
  solid
application(s)   HPLC: suitable
  gas chromatography (GC): suitable
color   pale yellow
solubility   ethanol: 11 mg/mL
  0.1 M HCl: 30 mg/mL
  DMSO: 4.8 mg/mL
format   neat
SMILES string   CN1CCN(CC1)C2=Nc3cc(Cl)ccc3Nc4ccccc24
InChI   1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
InChI key   QZUDBNBUXVUHMW-UHFFFAOYSA-N
Gene Information   human ... DRD2(1813), HTR2A(3356)

Description

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Atypical neuroleptic agent which displays greater affinity for the D4 dopamine receptor over D2 or D3 dopamine receptors; displays antipsychotic efficacy against positive and negative symptoms of schizophrenia in patients who do not respond to typical neuroleptics.

Safety & Documentation

Safety Information

RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
HP1750000

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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Description

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C6305 Clozapine

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