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C7145 Sigma

Cefamandole sodium salt

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Properties

Mode of action   cell wall synthesis | interferes

Description

Application

Cefamandole is used to study antibiotic resistance, the effects of expression and inhibition of penicillin-binding proteins, and the cooperation of antibiotics with host defence mechanisms .

Cefamandole is used to study the effects of expression and inhibition of PBP 2A and other penicillin-binding proteins (PDPs) on bacterial cell wall mucopeptide synthesis.

Biochem/physiol Actions

Cefamandole, a cephalosporin antibiotic, disrupts the synthesis of the peptidoglycan layer of bacterial cell walls. As Cefamandole is broken down in the body, it releases free N-methylthiotetrazole, which can cause hypoprothrombinemia .

General description

Chemical structure: ß-lactam

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
NONH for all modes of transport
WGK Germany 
2

Documents

Certificate of Analysis

Certificate of Origin

Protocols & Articles
Peer-Reviewed Papers
15

References

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