EMAIL THIS PAGE TO A FRIEND
C7602 Sigma

L-Cystine

from non-animal source, meets EP testing specifications, suitable for cell culture, 98.5-101.0%

Synonym: (R,R)-3,3′-Dithiobis(2-aminopropionicacid)

  • CAS Number 56-89-3

  • Linear Formula [-SCH2CH(NH2)CO2H]2

  • Molecular Weight 240.30

  •  Beilstein Registry Number 1728094

  •  EC Number 200-296-3

  •  MDL number MFCD00064228

  •  eCl@ss 32160406

  •  PubChem Substance ID 24892973

Purchase

Properties

Related Categories Amino Acids, Amino Acids & Derivatives, Amino Acids & Vitamins, Amino Acids and Vitamins, Amino acids,
biological source   non-animal source
InChI Key   LEVWYRKDKASIDU-IMJSIDKUSA-N
assay   98.5-101.0%
form   powder
impurities   endotoxin, tested
mp   >240 °C (dec.) (lit.)
solubility   1 M HCl: 100 mg/mL
suitability   meets EP testing specifications
  suitable for cell culture

Description

Packaging

1 kg in poly bottle

10 mg in glass bottle

25, 100 g in poly bottle

Application

L-Cystine has been used as a supplement in astroglial-conditioned media to culture cerebral astroglia. It has been used in several techniques, such as HPLC-FD, UHPLC-UV, UHPLC-MS, and triple quadrupole tandem mass spectrometry (UHPLC-MS/MS), to differentiate BMAA (β-N-methylamino-L-alanine), the cyanobacterial neurotoxin, from other diamino acids.
L-Cystine has been used as a supplement in oocyte culture media to improve oocyte maturation and parthenogenesis of embryonic development.

Biochem/physiol Actions

Cystinuria is characterized with renal transport and excretion of L-Cystine. Cysteine is one of the functional amino acids that are associated with growth, reproduction, maintenance and immunity. Cysteine is a source of disulfide linkage in protein and is associated with sulfur transport. At physiological pH, cysteine undergoes rapid oxidation to form cystine. Reduced availability of cysteine or cystine, influences leukocyte metabolism. L-Cystine is necessary for oxygen production and LDL (low density lipoprotein) modification by arterial smooth muscle cells.

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. C7602.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
1
RTECS 
HA2690000

Cell Culture Guide

Stabilizer Protein and RNA Stabilization Reagents
Protocols & Articles

Articles

MSMLS Online Plate Map

Metabolite descriptors included with the software download upon purchase of the product include: Name, Parent CID, molecular formula, molecular weight, CAS, ChEBI, HMDB ID, PubChem Compound and Subst...
Keywords: Mass spectrometry, Metabolites

Related Content

Amino Acids Reference Chart

The hydrophobicity index is a measure of the relative hydrophobicity, or how soluble an amino acid is in water. In a protein, hydrophobic amino acids are likely to be found in the interior, whereas h...
Keywords: Gene expression, Mass spectrometry

Cell Culture Troubleshooting Guide

Cell culture has become one of the most fundamental techniques for modeling biological systems, and is of increasing importance in the biotechnology and pharmaceutical sectors as well as an essential...
Keywords: Antibiotics, Apoptosis, Cell attachment, Cell culture, Cryopreservation, Filtration, Growth factors, Pharmaceutical, Phase transitions

L-cysteine and L-cysteine equivalents in Cell Culture

Importance and uses of cysteine in serum-free eucaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures
Keywords: Cell culture, Culture media, Lipid peroxidation, Oxidations, Peroxidations, Reductions

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?