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C8753 Sigma-Aldrich

Cholesteryl arachidonate

≥95% (HPLC; detection at 205 nm), viscous liquid

Synonym: 3β-Hydroxy-5-cholestene 3-arachidonate, 5-Cholesten-3β-ol 3-arachidonate, Cholesteryl eicosatetraenoate

  • CAS Number 604-34-2

  • Empirical Formula (Hill Notation) C47H76O2

  • Molecular Weight 673.11

  •  MDL number MFCD00056441

  •  PubChem Substance ID 24893099

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Properties

Related Categories Biochemicals and Reagents, Cell Biology, Cholesterol and Derivatives, Lipids, Metabolic Pathways,
InChI Key   IMXSFYNMSOULQS-SXXSVFILSA-N
assay   ≥95% (HPLC; detection at 205 nm)
form   viscous liquid
color   clear
shipped in   dry ice
storage temp.   −20°C

Description

Application

Cholesteryl arachidoante was oxidized and used to study the biological effects.

Packaging

10, 25 mg in glass bottle

Biochem/physiol Actions

Cholesteryl arachidonate is a cholesterol ester found associated with the neutral core of low density lipoprotein. Receptor-LDL complexes are taken up by lysosomes and hydrolyzed to release cholesterol from the esters. The enzyme acid cholesteryl ester hydrolase is responsible for the hydrolysis of cholesteryl esters; a defective enzyme can result in the formation of atherosclerotic lesions in humans.

Preparation Note

Cholesteryl arachidonate is a clear, colorless viscous liquid in chloroform.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Certificate of Origin

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Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Cholesterol Esterification

To more efficiently transport both dietary and synthesized cholesterol, it is converted to cholesteryl esters. Free cholesterol can be taken up by lipoproteins, but is confined to the outer surface o...
BioFiles 2007, 2.7, 10.
Keywords: Biofiles, Catalysis

Peer-Reviewed Papers
15

References

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