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C9033 Sigma-Aldrich

β-Chloro-L-alanine hydrochloride

Alanine aminotransferase inhibitor

  • CAS Number 51887-89-9

  • Empirical Formula (Hill Notation) C3H6ClNO2 · HCl

  • Molecular Weight 160.00

  •  MDL number MFCD00070398

  •  PubChem Substance ID 24278345

  •  NACRES NA.32

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Properties

Related Categories A to C, Alanine aminotransferase, Biochemicals and Reagents, Cell Biology, Cell Signaling and Neuroscience,
biological source   synthetic
assay   ≥98% (TLC)
form   powder
mp   205 °C
solubility   water: 50 mg/mL, clear, colorless
storage temp.   −20°C
SMILES string   Cl[H].N[C@@H](CCl)C(O)=O
InChI   1S/C3H6ClNO2.ClH/c4-1-2(5)3(6)7;/h2H,1,5H2,(H,6,7);1H/t2-;/m0./s1
InChI key   IENJPSDBNBGIEL-DKWTVANSSA-N

Description

Application

β-Chloro-L-alanine hydrochloride has been used:
• as a substrate for screening tyrosine phenol lyase steady state kinetics
• in the inhibition of serine palmitoyltransferase and cytotoxicity studies in lymphocyte Ly-1 cells
• as an inhibitor of alanine transaminase in wheat germ cell-free protein synthesis system

Biochem/physiol Actions

β-Chloro-L-alanine hydrochloride is an inhibitor of alanine aminotransferase (ALAT). Inhibition of ALAT leads to suppression of tumor progression in lung carcinoma.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Hazard statements 
Precautionary statements 
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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