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C9400 Sigma-Aldrich

Calcium Ionophore A23187 hemimagnesium salt

Synonym: A23187 hemimagnesium salt, Antibiotic A 23187 hemimagnesium salt, Calcimycin hemimagnesium salt, Calimycin hemimagnesium salt

  • CAS Number 72124-77-7

  • Empirical Formula (Hill Notation) C29H36Mg0.5N3O6

  • Molecular Weight 534.77

  •  Beilstein/REAXYS Number 6765085

  •  MDL number MFCD00151203

  •  PubChem Substance ID 24893158

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Properties

Related Categories A - K, Antibacterial, Antibiotics, Antibiotics A to Z, Antibiotics by Mechanism of Action,
Quality Level   200
Mode of action   cell membrane | interferes
antibiotic activity spectrum   Gram-positive bacteria
  fungi
storage temp.   2-8°C
SMILES string   CNc1ccc2oc(C[C@H]3O[C@@]4(CC[C@H]3C)O[C@@H]([C@H](C)C[C@H]4C)[C@H](C)C(=O)c5ccc[nH]5)nc2c1C(=O)O[Mg]OC(=O)c6c(NC)ccc7oc(C[C@H]8O[C@@]9(CC[C@H]8C)O[C@@H]([C@H](C)C[C@H]9C)[C@H](C)C(=O)c%10ccc[nH]%10)nc67
InChI   1S/2C29H37N3O6.Mg/c2*1-15-10-11-29(17(3)13-16(2)27(38-29)18(4)26(33)20-7-6-12-31-20)37-22(15)14-23-32-25-21(36-23)9-8-19(30-5)24(25)28(34)35;/h2*6-9,12,15-18,22,27,30-31H,10-11,13-14H2,1-5H3,(H,34,35);/q;;+2/p-2/t2*15-,16-,17-,18-,22-,27+,29+;/m11./s1
InChI key   XBWKBTZDBYFEMH-UIOMRPQBSA-L

Description

Packaging

5, 10 mg in glass bottle

Application

Ionophore highly selective for Ca2+. Potentiates responses to NMDA but not quisqualate. In cell culture, stimulates nitric oxide production by calmodulin-dependent constitutive nitric oxide synthase. Used to study effects of elevated intracellular calcium on mitochondrial function and intrinsic apoptosis.

Safety & Documentation

Safety Information

Symbol 
GHS07  GHS07
Signal word 
Warning
Target organs 
Respiratory system
Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
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