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D1944 Sigma-Aldrich

D4476

≥98% (HPLC), solid

Synonym: 4-(4-(2,3-Dihydrobenzo[1,4]dioxin-6-yl)-5-pyridin-2-yl-1H-imidazol-2-yl)benzamide

  • CAS Number 301836-43-1

  • Empirical Formula (Hill Notation) C23H18N4O3

  • Molecular Weight 398.41

  •  PubChem Substance ID 329798715

  •  NACRES NA.77

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Casein Kinase (CK), Cell Biology,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
color   light yellow
solubility   DMSO: ~20 mg/mL
  H2O: insoluble
originator   GlaxoSmithKline
  GlaxoSmithKline
storage temp.   2-8°C
SMILES string   NC(=O)c1ccc(cc1)-c2nc(-c3ccccn3)c([nH]2)-c4ccc5OCCOc5c4
InChI   1S/C23H18N4O3/c24-22(28)14-4-6-15(7-5-14)23-26-20(21(27-23)17-3-1-2-10-25-17)16-8-9-18-19(13-16)30-12-11-29-18/h1-10,13H,11-12H2,(H2,24,28)(H,26,27)
InChI key   DPDZHVCKYBCJHW-UHFFFAOYSA-N

Description

Application

D4476 has been used as a casein kinase I inhibitor (CKI) in various experiments.

Packaging

1, 5 mg in glass bottle

Biochem/physiol Actions

D4476 may prevent or enhance apoptosis. It triggers tumor suppressor p53 and impairs transcription factor E2F-1.

D4476 is a potent, selective ATP-competitive inhibitor of CK1 (casein kinase 1).

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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