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D3648 Sigma-Aldrich

Diamide

Synonym: 1,1′-Azobis(N,N-dimethylformamide), N,N,N′,N′-Tetramethylazodicarboxamide, Azodicarboxylic acid bis(dimethylamide), Diazenedicarboxylic acid bis(N,N-dimethylamide), TMAD

  • CAS Number 10465-78-8

  • Linear Formula (CH3)2NCON=NCON(CH3)2

  • Molecular Weight 172.19

  •  Beilstein/REAXYS Number 1910409

  •  EC Number 233-951-7

  •  MDL number MFCD00008318

  •  PubChem Substance ID 24278365

  •  NACRES NA.22

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Properties

Related Categories Active Esters/Additives, Biochemicals and Reagents, Chemical Synthesis, Coupling, D to K,
Quality Level   200
assay   ≥98% (TLC)
form   powder
mp   113-115 °C
solubility   water: 19.60-21.00 mg/mL, clear to slightly hazy, orange
storage temp.   −20°C
SMILES string   CN(C)C(=O)\N=N\C(=O)N(C)C
InChI   1S/C6H12N4O2/c1-9(2)5(11)7-8-6(12)10(3)4/h1-4H3/b8-7+
InChI key   VLSDXINSOMDCBK-BQYQJAHWSA-N

Description

Application

Reported to be of use as a thiol oxidizing agent. Diamide has been used to titrate protein glutathiolation to discriminate from other oxidative protein modifications. Treatment increased protein glutathiolation in a concentration-dependent manner and had comparably little effect on protein-protein disulfide formation.

Packaging

5 g in glass bottle

Safety & Documentation

Safety Information

Personal Protective Equipment 
RIDADR 
NONH for all modes of transport
WGK Germany 
WGK 3
RTECS 
LQ1041000
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable
Protocols & Articles
Peer-Reviewed Papers
15

References

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Description

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92210 Timestrip Plus 0 °C
06693 Timestrip Plus -20 °C

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