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D3821 Sigma-Aldrich

Devazepide

≥98% (HPLC), powder

Synonym: (S)-N-(2,3-Dihydro-1-methyl-2-oxo-5-phenyl-1H-1,4-benzodiazepin-3-yl)indole-2-carboxamide, L-364,718, MK 329

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Properties

Related Categories Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, D-DIF,
InChI Key   NFHRQQKPEBFUJK-HSZRJFAPSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   desiccated
color   white to off-white
solubility   DMSO: >5 mg/mL
originator   Merck & Co., Inc., Kenilworth, NJ
storage temp.   2-8°C

Description

General description

Devazepide is derived from asperlicin by chemical modification and has the benzodiazepine backbone.

Application

Devazepide has been used as a cholecystokinin receptor 1 (CCK1R) antagonist in human embryonic kidney 293T cells and in human pancreatic slices.

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Devazepide is a CCK1 (CCK-A) receptor antagonist and a CCK8 antagonist.

Devazepide is a cholecystokinin octapeptide (CCK1) (CCK-A) receptor antagonist. It inhibits CCK binding to peripheral-type receptor (CCK-A). Devazepide reverses the cholecystokinin octapeptide (CCK-8) based antagonism towards morphine.

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

Symbol 
GHS06  GHS06
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGI
WGK Germany 
3
RTECS 
NL5994460

Documents

Certificate of Analysis

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Making Headway

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Protocols & Articles
Peer-Reviewed Papers
15

References

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