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D3943 Sigma-Aldrich

DAPH

≥98% (HPLC), solid

Synonym: 4,5-Dianilinophthalimide, 5,6-Bis(phenylamino)-1H-isoindole-1,3(2H)-dione, CGP 52411

  • CAS Number 145915-58-8

  • Empirical Formula (Hill Notation) C20H15N3O2

  • Molecular Weight 329.35

  •  MDL number MFCD00236442

  •  PubChem Substance ID 24724461

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, D-DIF
InChI Key   AAALVYBICLMAMA-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   solid
color   orange
solubility   DMSO: >20 mg/mL
  H2O: insoluble
storage temp.   2-8°C
Gene Information   human ... EGFR(1956)

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

DAPH is an inhibitor of Aβ fibril formation; Protein tyrosine kinase inhibitor, specific for EGFR.

Features and Benefits

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC®1280), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound is featured on the EGFR page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

LOPAC is a registered trademark of Sigma-Aldrich Co. LLC

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cytokines & Growth Factors Research

Cytokines and growth factors (GF) are chemical messengers that mediate intracellular communication, thereby regulating cellular and nuclear functions. These chemical messengers bind cell surface rece...
Keywords: Biological processes, Cancer, Cell proliferation, Diseases, Growth factors, Ligands, Phosphorylations, Transcription, Transduction

EGFR

Epidermal growth factor receptor (EGFR), its family members Her-2/ErbB-2, Her-3, Her-4 and their ligands, are involved in over 70% of all cancers. EGFR itself has been implicated in ~30% of all solid...
Keywords: Angiogenesis, Atomic absorption spectroscopy, Clinical, Electron spin resonance, Gastrointestinal, Gene expression, Growth factors, Indicators, Ligands, Phosphorylations, Transduction

Peer-Reviewed Papers
15

References

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