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D6696 Sigma-Aldrich

Doramectin synthetic

Synonym: 25-Cyclohexyl-5-O-demethyl-25-de(1-methylpropyl)avermectin, Doramectin

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Properties

biological source   synthetic
InChI Key   QLFZZSKTJWDQOS-TTXKVKCHSA-N
assay   ≥90%
form   solid
impurities   ≤5% water (Karl Fischer)
color   white
solubility   methanol: soluble
Mode of action   cell membrane | interferes
antibiotic activity spectrum   parasites
storage temp.   −20°C

Description

Packaging

100 mg in poly bottle

Application

Doramectin is commonly used in veterinary medicine for the treatment of parasites such as gastrointestinal roundworms, lungworms, eyeworms, grubs, sucking lice and mange mites. It is effective against Haemonchus spp., Ostertagia spp., Trichostrongylus spp., Cooperia spp., Oesophagostomum spp., Dyctiocaulus viviparus, Dermatobia hominis, Boophilus microplus, Psoroptes bovis, as well as other internal and external parasites.

Biochem/physiol Actions

Doramectin is a derivative of ivermectin. It is thought to work like other macrocyclic lactones by opening glutamate-gated chloride channels in the nerve cells, causing paralysis.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3

Documents

Certificate of Analysis

Protocols & Articles
Peer-Reviewed Papers
15

References

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