EMAIL THIS PAGE TO A FRIEND
D7696 Sigma-Aldrich

Demethoxycurcumin

≥98% (HPLC)

Synonym: (E,E)-1-(4-Hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5-dione, Curcumin II, Desmethoxycurcumin, Monodemethoxycurcumin

Purchase

Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, D-DIF
InChI Key   HJTVQHVGMGKONQ-LUZURFALSA-N
assay   ≥98% (HPLC)
form   powder
storage condition   protect from light
color   orange
solubility   DMSO: ≥10 mg/mL
storage temp.   2-8°C

Description

Packaging

5, 25 mg in glass bottle

Biochem/physiol Actions

Demethoxycurcumin (DMC) is a derivative or curcumin, and represents one of the major active components of curcumin products isolated from Curcumae sp. DMC inhibits LPS-induced nitric oxide (NO) production, and expression of iNOS and COX2 in RAW264.7 cells by blocking NF-kB activation. DMC also inhibits NF-kB dependent iNOS, TNFα and IL-1β expression in LPS-treated rat microglial cells. DMC suppresses expression of MMPs and ICAM-1 in MDA-MB-231 human breast cancer cells by inhibition of NF-kB.

Safety & Documentation

Safety Information

Symbol 
GHS09  GHS09
Signal word 
Warning
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
2

Documents

Certificate of Analysis


Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

UHPLC Analysis of Curcumins on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Curcumins on Ascentis® Express RP-Amide
Keywords: Vitamins

UHPLC Analysis of Turmeric Curcumin Herbal Supplement on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Turmeric Curcumin Herbal Supplement on Ascentis® Express RP-Amide
Keywords: Chromatography, Sample preparations, Vitamins

UHPLC Analysis of Turmeric Standards on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents UHPLC Analysis of Turmeric Standards on Ascentis® Express RP-Amide
Keywords: Chromatography, Vitamins

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?