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D9069 Sigma-Aldrich

N-Desmethyltamoxifen HCl

≥98% (HPLC), solid

Synonym: (Z)-2-(p-(1,2-Diphenyl-1-butenyl)phenoxy)-N-methylethylamine, ICI 55,548

  • CAS Number 15917-65-4

  • Empirical Formula (Hill Notation) C25H27NO·HCl

  • Molecular Weight 393.95

  •  MDL number MFCD03423594

  •  PubChem Substance ID 329798889

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, Cell Signaling and Neuroscience, Cytokines, Growth Factors and Hormones,
Quality Level   100
assay   ≥98% (HPLC)
form   solid
application(s)   inhibition assay: suitable
solubility   DMSO: ≥20 mg/mL
shipped in   ambient
storage temp.   room temp
SMILES string   Cl.CC\C(c1ccccc1)=C(/c2ccccc2)c3ccc(OCCNC)cc3
InChI   1S/C25H27NO.ClH/c1-3-24(20-10-6-4-7-11-20)25(21-12-8-5-9-13-21)22-14-16-23(17-15-22)27-19-18-26-2;/h4-17,26H,3,18-19H2,1-2H3;1H/b25-24-;
InChI key   GMLHJWZEYLTNJW-BJFQDICYSA-N

Description

Application

N-Desmethyltamoxifen HCl has been used as an internal standard in high-performance liquid chromatography (HPLC) for the quantification of metabolites from NG2 cell-derived astrocytes.

Packaging

5 mg in glass bottle

Biochem/physiol Actions

N-Desmethyltamoxifen HCl is the primary metabolite of tamoxifen. N-Desmethyltamoxifen HCl is an estrogen response modifer and protein kinase C inhibitor.

Features and Benefits

This compound is featured on the Nuclear Receptors (Steroids) and PKC pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
Precautionary statements 
RIDADR 
UN 3077 9 / PGIII
WGK Germany 
WGK 3
Flash Point(F) 
Not applicable
Flash Point(C) 
Not applicable

Documents

Certificate of Analysis (COA)

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Protocols & Articles

Articles

HPLC Analysis of Tamoxifen E/Z isomers and Related Compounds on Ascentis® Express RP-Amide

From our library of Articles, Sigma-Aldrich presents HPLC Analysis of Tamoxifen E/Z isomers and Related Compounds on Ascentis® Express RP-Amide
Keywords: Chromatography, High performance liquid chromatography, Pharmaceutical

Nuclear Receptors (Steroids)

Intracellular receptors (IRs) are a class of ligand-dependent transcription factors that include receptors for both steroid and non-steroid hormones. Upon binding their cognate hormone, these recepto...
Keywords: Anti-inflammatory agents, Apoptosis, Atomic absorption spectroscopy, Cancer, Cardiovascular, Cell proliferation, Diseases, Diuretics, Gene expression, Hormones, Infrared spectroscopy, Ligands, Metabolism, Metabolites, Transcription, Transduction

PKC

Protein kinase C (PKC) is an AGC kinase that phosphorylates serine and threonine residues in many target proteins. It was first identified in 1977 in bovine cerebellum by Nishizuka and co-workers as ...
Keywords: Apoptosis, Atomic absorption spectroscopy, Biological processes, Cancer, Catalysis, Cell signaling, Degradations, Diabetes, Gastrointestinal, Gene expression, Immobilization, Phosphorylations, Pulsed discharge ionization detector, Transcription, Ubiquitinations

Peer-Reviewed Papers
15

References

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