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D9286 Sigma-Aldrich

Paraoxon-ethyl

≥90%, oil

Synonym: O,O-Diethyl O-(4-nitrophenyl) phosphate, Diethyl p-nitrophenyl phosphate, Paraoxon-ethyl, Paraoxon

  • CAS Number 311-45-5

  • Linear Formula O2NC6H4OP(O)(OC2H5)2

  • Molecular Weight 275.20

  •  Beilstein/REAXYS Number 1915526

  •  EC Number 206-221-0

  •  MDL number MFCD00007316

  •  PubChem Substance ID 24894279

  •  NACRES NA.77

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Properties

Related Categories Biochemicals and Reagents, Enzyme Substrates, Enzymes, Inhibitors, and Substrates, Esterase, Substrates by Enzyme More...
assay   ≥90%
form   oil
color   yellow
refractive index   n20/D 1.51 (lit.)
density   1.274 g/mL at 25 °C (lit.)
storage temp.   2-8°C
SMILES string   CCOP(=O)(OCC)Oc1ccc(cc1)[N+]([O-])=O
InChI   1S/C10H14NO6P/c1-3-15-18(14,16-4-2)17-10-7-5-9(6-8-10)11(12)13/h5-8H,3-4H2,1-2H3
InChI key   WYMSBXTXOHUIGT-UHFFFAOYSA-N
Gene Information   human ... PON1(5444)

Description

Application

Paraoxon-ethyl has been used as a substrate in paraoxonase (PON) activity assay. It has also been used as a lipase inhibitor to study the effects of anacetrapib on homotypic transfer from high density lipoprotein L3 (HDL3) to HDL2 in vivo.

Packaging

1 g in glass bottle

Biochem/physiol Actions

Potent irreversible acetylcholinesterase inhibitor

Caution

air sensitive: handle under argon

Physical form

Oily liquid

Other Notes

Tandem Mass Spectrometry data independently generated by Scripps Center for Metabolomics is available to view or download in PDF. D9286.pdf Tested metabolites are featured on Scripps Center for Metabolomics METLIN Metabolite Database. To learn more, visit sigma.com/metlin.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN2810 - class 6.1 - PG 1 - MP - RQ - Toxic, liquids, organic, n.o.s., HI: all
WGK Germany 
3
RTECS 
TC2275000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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