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D9315 Sigma-Aldrich

Deltamethrin

≥98%

  • CAS Number 52918-63-5

  • Empirical Formula (Hill Notation) C22H19Br2NO3

  • Molecular Weight 505.20

  •  Beilstein/REAXYS Number 6746312

  •  EC Number 258-256-6

  •  MDL number MFCD00870122

  •  PubChem Substance ID 24724471

  •  NACRES NA.77

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Calcium Antagonists, Cell Biology, Cell Signaling and Neuroscience,
Quality Level   100
assay   ≥98%
storage temp.   −20°C
SMILES string   CC1(C)[C@@H](\C=C(\Br)Br)[C@H]1C(=O)O[C@H](C#N)c2cccc(Oc3ccccc3)c2
InChI   1S/C22H19Br2NO3/c1-22(2)17(12-19(23)24)20(22)21(26)28-18(13-25)14-7-6-10-16(11-14)27-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3/t17-,18+,20-/m0/s1
InChI key   OWZREIFADZCYQD-NSHGMRRFSA-N

Description

Application

Deltamethrin has been used to study its effect:
• as a PP2A/PPP3CA inhibitor by treating HEK293 (human embryonic kidney cells) Tau-BiFC cells
• on the innate immunity in rainbow trout
• on the molecular stress level in black tiger shrimp Penaeus monodon

Packaging

10 mg in ampule

Biochem/physiol Actions

Deltamethrin is a type II semi-synthetic pyrethrin, which acts as a potent inhibitor of calcineurin (protein phosphatase 2B) and has an IC50 of about 100 pM. This inhibitory action results in cellular hyperexcitability by causing non-mutated calcium channels to remain open for an extended period of time allowing an abundance of Ca2+ to enter the cell. Some sodium channel mutations such as the L993F mutation in Xenopus oocytes show decreased sensitivity to deltamethrin.

Safety & Documentation

Safety Information

Symbol 
Signal word 
Danger
Hazard statements 
RIDADR 
UN2811 - class 6.1 - PG 2 - EHS - Toxic solids, organic, n.o.s., HI: all
WGK Germany 
WGK 3
RTECS 
GZ1233000

Documents

Certificate of Analysis (COA)

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Certificate of Origin (COO)

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Protocols & Articles
Peer-Reviewed Papers
15

References

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