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E1657 Sigma-Aldrich

EHT 1864

≥98% (HPLC)

Synonym: 5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride

  • CAS Number 754240-09-0

  • Empirical Formula (Hill Notation) C25H27F3N2O4S · 2HCl

  • Molecular Weight 581.47

  •  MDL number MFCD11114384

  •  PubChem Substance ID 329799014

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Properties

Related Categories Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules, Cell Biology, E
InChI Key   LSECOAJFCKFQJG-UHFFFAOYSA-N
assay   ≥98% (HPLC)
form   powder
color   white to beige
solubility   H2O: 10 mg/mL, clear
storage temp.   2-8°C

Description

Application

EHT 1864 has been used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity.

Packaging

10 mg in glass bottle

Biochem/physiol Actions

EHT 1864 induces dissociation of bound nucleotides. EHT 1864 induced inhibition of Rac prevents its association with downstream effectors. It is known to prevent estrogen-induced tumor cell proliferation in breast cancer.

EHT 1864 inhibits Rac function. It prevents Aβ40 and Aβ42 production in vitro without direct inhibition of g-secretase.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the GTP Binding Proteins (Low Molecular Weight) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Legal Information

EHT 1864 compound sold under license from ExonHit Therapeutics S.A. (www.exonhit.com)

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
3

Documents

Certificate of Analysis

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Making Headway

Milli-Q® Water Purification Solutions
Protocols & Articles

Articles

Discover Bioactive Small Molecules for Cyclic Nucleotides

Transmission of an extracellular signal across the cell membrane is initiated by activation of many types of hormone and neurotransmitter receptors, such as G-protein coupled receptors (GPCRs), and c...
Keywords: Antivirals, Cancer, Cardiovascular, Cellular processes, Diabetes, Diseases, Hormones, Neurotransmitters

GTP Binding Proteins (Low Molecular Weight)

The approximately 150 members of the human Ras superfamily of low molecular weight GTP binding proteins function as regulators of diverse cellular processes. Most Ras superfamily members have intrins...
Keywords: Absorption, Acetylations, Atomic absorption spectroscopy, Cancer, Cellular processes, Diseases, Enzyme activity, Farnesylations, Geranylgeranylations, Myristoylations, Palmitoylations, Post translational modifications, Rearrangements, Transduction

Peer-Reviewed Papers
15

References

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