• USA Home
  • E6888 - Enalapril maleate salt

EMAIL THIS PAGE TO A FRIEND
E6888 Sigma-Aldrich

Enalapril maleate salt

powder, ≥98% (TLC)

Synonym: (S)-N-[1-(Ethoxycarbonyl)-3-phenylpropyl]-Ala-Pro maleate salt

  • CAS Number 76095-16-4

  • Empirical Formula (Hill Notation) C20H28N2O5 · C4H4O4

  • Molecular Weight 492.52

  •  EC Number 278-375-7

  •  PubChem Substance ID 24894639

Purchase

Properties

Related Categories Angiotensin Metabolism, Angiotensins, Approved Therapeutics/Drug Candidates, Bioactive Small Molecule Alphabetical Index, Bioactive Small Molecules,
InChI Key   UQKQUZOIQFOJOI-KJHLASMFSA-N
assay   ≥98% (TLC)
form   powder
color   white to off-white
solubility   methanol: ≥50 mg/mL, clear, colorless to yellow
originator   Merck & Co., Inc., Kenilworth, NJ

Description

General description

Enalapril is an angiotensin-converting enzyme inhibitor. It is used to treat heart failure and high blood pressure.

Application

Enalapril maleate salt has been used:
• to reduce albumin excretion rate (AER) and glomerular lesions
• to examine the effects of enalapril pre-treatment on myocardial injury
• to investigate its efficacious doses and schedules for mitigation of radiation lung injury

Packaging

1, 5 g in poly bottle

250 mg in poly bottle

Biochem/physiol Actions

A long-acting angiotensin-converting enzyme inhibitor.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound was developed by Merck & Co., Inc., Kenilworth, NJ. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Safety & Documentation

Safety Information

RIDADR 
NONH for all modes of transport
WGK Germany 
2
RTECS 
TW3666000

Documents

Certificate of Analysis

???PDP_SDS_LOT_NUMBER_ERROR_MSG???

Certificate of Origin

???PDP_SDS_LOT_NUMBER_ERROR_MSG???
Protocols & Articles

Articles

Antihypertensive Agents

Download BioFiles v7 n5 (3.18 Mb PDF) Back to Pharmaceutical Drugs and Drug Candidates homepage
Sami Barghshoon
BioFiles v7 n5, 2012, 5–20
Keywords: AGE, Antihypertensives, Cardiovascular, Clinical, Diuretics, PAGE, Pharmaceutical, Reductions

Discover Bioactive Small Molecules for ADME/Tox

A significant number of drugs that fail in clinical trials have been associated with safety issues, including unexpected drug-drug interactions (DDI) or lack of efficacy due to poor pharmacokinetics....
Keywords: Absorption, Bioactive small molecules, Clinical, Metabolism

Peer-Reviewed Papers
15

References

Related Products

Technical Service:

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Bulk Ordering & Pricing:

Need larger quantities for your development, manufacturing or research applications?